Microporosities in 3D-Printed Tricalcium-Phosphate-Based Bone Substitutes Enhance Osteoconduction and Affect Osteoclastic Resorption. Ghayor, Chafik Chen, Tse-Hsiang Bhattacharya, Indranil Özcan, Mutlu Weber, Franz E (2020).

European Cells and Materials (ECM), 41:233-244. Therapeutic potential of mesenchymal stem cell-derived extracellular vesicles in regenerative endodontics. Ivica, A Zehnder, M Weber, F E (2021).The optimal microarchitecture of 3D-printed β-TCP bone substitutes for vertical bone augmentation differs from that for osteoconduction. Ghayor, Chafik Bhattacharya, Indranil Weber, Franz E (2021).Toxicology and applied pharmacology, 423:115568. Exposure to the bromodomain inhibitor N-methyl pyrrolidone blocks spermatogenesis in a hormonal and non-hormonal fashion. Khera, Nupur Ghayor, Chafik Pavlova, Ekaterina Atanassova, Nina Weber, Franz E (2021).International Journal of Molecular Sciences, 22(20):11052. Effect of N-Vinyl-2-Pyrrolidone (NVP), a Bromodomain-Binding Small Chemical, on Osteoblast and Osteoclast Differentiation and Its Potential Application for Bone Regeneration. Klemmer, Viviane A Khera, Nupur Siegenthaler, Barbara M Bhattacharya, Indranil Weber, Franz E Ghayor, Chafik (2021).Repair of bone defects using synthetic mimetics of collagenous extracellular matrices. Lutolf MP, Weber FE, Schmoekel HG, Schense JC, Kohler T, Müller R and JA Hubbell (2003). Engineering 3D cell instructive microenvironments by rational assembly of artificial extracellular matrices and cell patterning. Sala A, Hänseler P, Ranga A, Lutolf MP, Vörös J, Ehrbar M, Weber FE. Karfeld-Sulzer L.S., Ghayor C., Siegenthaler B., de Wild M., Leroux J.-C., Weber FE (2015) N-methyl Pyrrolidone/Bone Morphogenetic Protein-2 Double Delivery with In Situ Forming Implants Ghayor C., Gjoksi B., Dong J., Siegenthaler B., Caflisch A., Weber FE (2017) N,N Dimethylacetamide a drug excipient that acts as bromodomain ligand for osteoporosis treatment.ĭe Wild M, Zimmermann S, Rüegg J, Schumacher R, Fleischmann T, Ghayor C, Weber FE (2016) Influence of microarchitecture on osteoconduction and mechanics of porous titanium scaffolds generated by selective laser meltingģD printing + Additve manufacturing, 3(3): 143-151 Ghayor C & Weber FE (2018) Osteoconductive microarchitecture of bone substitutes for bone regeneration revisited.įront. Ivica A, Zehnder M, Mateos JM, Ghayor C, and Weber FE (2019) Biomimetic Conditioning of Human Dentin Using Citric Acid. Moreover, we work on the regeneration of the pulp using natural and synthetic hydrogels and diverse factors with the aim to extend the lifetime of teeth. The delivery of osteoinductive bone morphogenetic proteins, including epigenetically active enhancers of bone morphogenetic proteins and degradable, bioactive guided bone regeneration membranes are other fields of expertise of our laboratory. The materials we use and develop range from degradable polylactide based materials, to natural and synthetic hydrogels, like fibrin and polyethylenglycol-(PEG)-based hydrogels, to titanium and ceramic based scaffolds produced in a patient specific shape by additive manufacturing. Based on our capabilities to design and produce ceramic based scaffolds with additive manufacturing, we try to unravel the essence of osteoconduction as important driving force of bone regeneration. To overcome this problem our oral Biotechnology and Bioengineering laboratory works on the development of new osteoconductive bone substitute materials and their combination with osteoinductive bone morphogenetic proteins, and epigenetically active small molecules. In cranio-maxillofacial and oral surgery the substitution of a mandible to restore resections of tumors for example, still poses a great challenge.

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